A popular technique: hybrid method Limitations Numerical rather than physical Artifacts Time coupling MD NS Dynamic scale changes International Journal for Multiscale Computational Engine Athough hybrid methods provide signifi- Hadjiconstantinou cant savings by limiting molecular solutions IntJ Multiscale Comput Eng 3 189-202, 2004 only to the regions where they are needed, so- lution of time-evolving problems, which span a large range of timescales, is still not possible Discussion of Hybrid if the molecular domain, however small needs Atomistic-Continuum method to be integrated for the total time of interest for Multiscale hydrodynamics Hybrid method is inappropriate for problems with dynamic scale changesA popular technique: hybrid method MD NS Limitations Artifacts Time coupling Numericalrather than physical Dynamic scale changes Hadjiconstantinou Int J Multiscale Comput Eng 3 189-202, 2004 Hybrid method is inappropriate for problems with dynamic scale changes