发病机制 TNF FasR 7-IFN 7-IFN ● toxicity for CTL -IFN-R other cells T-cells ↑ICE apoptosis TNF-R 1RF-1 NO TNF Jak1 dsRNA-PKR L-2 Stat1 ! 正 RNaseL elF.2 Stat3 ↓cell cycling ↓protein synthesis hematopoietic cell AVAF0 CTL直接杀伤HSC clonal 淋巴因子介导HSC凋亡 expansion Y2济9 发病机制 CTL直接杀伤 HSC 淋巴因子介导HSC凋亡