Normal hemostasis and coagulation (3)fibrin: fibrinogen thrombinfibrin monomer-polymerxllapolymer (4) function of thrombin coagulation: activate I、Ⅻ strengthenⅧ、V platelet: aggregation, release fibrinolysis: activate plasminogenNormal hemostasis and coagulation （3）fibrin：fibrinogenthrombinfibrin monomer-polymerXIIIapolymer （4）function of thrombin： coagulation：activateⅠ、Ⅻ、 strengthen Ⅷ、Ⅴ platelet：aggregation, release fibrinolysis：activate plasminogen