上游充通大淫 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Aldosterone antagonist Spironolactone Aldosterone antagonist,K-sparing diuretic Prevention of aldosterone effects on: Kidney -Heart? ● Aldosterone inappropriately elevated in CHF Mobilizes edema fluid in heart failure ● Prevention of hypokalemia induced by loop diuretics(protection against digitalis toxicity?) Prolongs life in CHF patientsAldosterone antagonist Aldosterone antagonist  Aldosterone antagonist, K-sparing diuretic  Prevention of aldosterone effects on: – Kidney – Heart?  Aldosterone inappropriately elevated in CHF  Mobilizes edema fluid in heart failure  Prevention of hypokalemia induced by loop diuretics (protection against digitalis toxicity?)  Prolongs life in CHF patients Spironolactone Spironolactone