Targeted inhibition of gene expression Add TFO GENE TFO N个， +000V Template (antisense)strand Sense DNA strand mRNA Add antisense 5 AAAAAA 3' AAAA 3' oligodeoxynucleotide or an antisense gene which is transcribed to give a (a) Inhibition of translation specific antisense RNA or (b)(i)If a ribozyme,direct cleavage a ribozyme of mRNA (b)(ii)If an oligodeoxynucleotide the mRNA of the RNA-DNA hybrid is cleaved by RNase HTargeted inhibition of gene expression