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The emerging science of epigenomics. Hum. Mol. Genet.15, R95–R101 (2006). 96. Mack, G. S. Epigenetic cancer therapy makes headway. J. Natl Cancer Inst. 98, 1443–1444 (2006). 97. Yee, K. W., Jabbour, E., Kantarjian, H. M. & Giles, F. J. Clinical experience with decitabine in North American patients with myelodysplastic syndrome. Ann Hematol 84 (Suppl. 13), 18–24 (2005). 98. Zheng, Y. et al. Selective HAT inhibitors as mechanistic tools for protein acetylation. Methods Enzymol. 376, 188–199 (2004). 99. Iyer, N. G., Ozdag, H. & Caldas, C. p300/CBP and cancer. Oncogene 23, 4225–4231 (2004). 100. Phiel, C. J. et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J. Biol. Chem. 276, 36734–36741 (2001). Acknowledgements I thank H. Bjornsson, R. Ohlsson, T. Ekstrom, D. Gius and C. Ladd-Acosta for their many thoughtful insights, and J. Fairman for her artistry. This work was supported by a grant from the NIH. Author Information Reprints and permissions information is available at npg.nature.com/reprintsandpermissions. The author declares no competing financial interests. Correspondence should be addressed to the author (afeinberg@jhu.edu). 440 INSIGHT REVIEW NATURE|Vol 447|24 May 2007 ￾