1.1.4 The first protein with a single amino acid substitution being related to a genetic disease (the beginning of molecular medicine) 1.1.5 The first multisubunit protein with its detailed atomic structure determined by x- ray crystallography. 1.1.6 The best understood allosteric pl rotein。1.1.4 The first protein with a single amino acid substitution being related to a genetic disease (the beginning of molecular medicine). 1.1.5 The first multisubunit protein with its detailed atomic structure determined by X￾ray crystallography. 1.1.6 The best understood allosteric protein