2. Pathogenesis There are three major factors may account for the development of ARF(ATN) 1. Renal hemodynamic factors 1. Alteration of renal hem odynamics 2. Nephronal factors 2. Renal tubule injury 3. Filtration area and permeability 3. Decreased ultrafiltration coefficient( Kf)of glomerul 2323 There are three major factors may account for the development of ARF(ATN): 1. Renal hemodynamic factors 2. Nephronal factors 3. Filtration area and permeability 2. Pathogenesis 1. Alteration of renal hemodynamics 2. Renal tubule injury 3. Decreased ultrafiltration coefficient (Kf) of glomeruli