XPID:X-linked polyendocrinopathy, immune dysfunction and diarrhea ·XLAAD:“Autoimmunity Allergic Dysreg Scurfin gene (Foxp3/JM2) Immunopathogenesis:Th2 Cytokines, abnormal activation (I1-4,5,13) -Scurfy+Nude:No Autoimmunity -CD4+into Nude:Disease -Bone Marrow into irradiated:No Disease -Require Antigen Stimulation for Disease -Mixed Chimera:No Disease BDC XPID: X-linked polyendocrinopathy, immune dysfunction and diarrhea • XLAAD: “Autoimmunity Allergic Dysreg” • Scurfin gene (Foxp3/JM2) • Immunopathogenesis: Th2 Cytokines, abnormal activation (Il-4,5,13) -Scurfy+Nude: No Autoimmunity -CD4+ into Nude: Disease -Bone Marrow into irradiated: No Disease -Require Antigen Stimulation for Disease -Mixed Chimera: No Disease BDC