AD病理与认知功能损害机制 AB InsR ▲中tam时t critic NFT Cholinergic Deficit Cell Glutamate deficitNeuritic Plaque AD病理与认知功能损害机制 Genes Aβ NFT Oxidation Excitotoxicity Cell Death Cholinergic Deficit NMDA receptor AMPA receptor Glutamate Magnesium Glutamate Deficit Environment Ins RInsR age