Antigens To cause immunologically mediated renal disease, an antigen must localize to the kidney and trigger a local immune inflammatory response. Renal antigens are inherently localized, being constituent proteins of the kidney Non-renal antigens require a mechanism for depositing in the kidneyAntigens • To cause immunologically mediated renal disease, an antigen must localize to the kidney and trigger a local immune inflammatory response. • Renal antigens are inherently localized, being constituent proteins of the kidney. • Non-renal antigens require a mechanism for depositing in the kidney