115 The large scale production of organic acids by mIcro-organIsms 5.1 Introduction 116 5.2 Metabolic pathways and metabolic control mechanisms 5.3 The industrial production of citric acid 5.4 The production of other TCA cycle intermediates 5.5 The industrial production of itaconic acid 5.6 The industrial production of gluconolactone and gluconic acid 142 Summary and objectives115 The large scale production of organic acids by micrwrganisms Overview 5.1 Introduction 5.2 Metabolic pathways and metabolic control mechanisms 5.3 The industrial production of atric acid 5.4 The production of other TCA cycle intermediates 5.5 The industrial production of itaconic acid 5.6 The industrial production of gluconoladone and gluconic acid Summary and objectives 116 116 120 125 137 138 142 146