Vaughn-Williams Classification Based on cellular properties of normal His-Purkinje cells Classified on drug's ability to block specific ionic currents (i.e. Nat, K*+, Ca**) and beta-adrenergic receptors Advantages: Physiologically based Highlights beneficialldeleterious effects of specific drugsVaughn-Williams Classification • Based on cellular properties of normal His-Purkinje cells • Classified on drug’s ability to block specific ionic currents (i.e. Na+ , K+ , Ca++) and beta-adrenergic receptors • Advantages: – Physiologically based – Highlights beneficial/deleterious effects of specific drugs