Drug distribution Apparent volume of distribution Plasma (4L) Interstitial fluid (10L) Intracellular fluid (28L) A B Calculation of the Vd 50.00 Distribution phase (a) 5.00 0.50 Co Elimination phase (B) 6nup 0.05 0.00 0 Time 500mg Dose 500mg injected IV Vd= =100L Co 5 mg/L C