Complement activation A system of plasma proteins that interact with Antigen/antibody complexes Pathogen surface motifs(alternative and lectin pathways Activation of complement results in Chemo-attraction of inflammatory cells Peptide mediators of inflammation (anaphylatoxins) Increased blood vessel permeability Smooth muscle contraction Mast cell degranulation Opsonization of pathogens (enhances phagocytosis) Killing of pathogens(membrane attack complex) Complement activation ◼ A system of plasma proteins that interact with ◼ Antigen/antibody complexes ◼ Pathogen surface motifs (alternative and lectin pathways ◼ Activation of complement results in ◼ Chemo-attraction of inflammatory cells ◼ Peptide mediators of inflammation (anaphylatoxins) ◼ Increased blood vessel permeability ◼ Smooth muscle contraction ◼ Mast cell degranulation ◼ Opsonization of pathogens (enhances phagocytosis) ◼ Killing of pathogens (membrane attack complex)