Concepts Prokaryotes are small and simple in structure when compared with eukaryotes,yet they often have characteristic shape and size. Prokaryotic genetic material is located in an area called the nucleoid and is not enclosed by a membrane. The prokaryotic cell wall almost always has peptidoglycan and is chemically and morphologically complex.Concepts • Prokaryotes are small and simple in structure when compared with eukaryotes , yet they often have characteristic shape and size. • Prokaryotic genetic material is located in an area called the nucleoid and is not enclosed by a membrane. • The prokaryotic cell wall almost always has peptidoglycan and is chemically and morphologically complex