3. Effects of hepatic failure on the body (1) Disturbance of metabolism carbohydrate protein electrolyte (2)Obstacle of bile secrete and excrete hyperbilirubinemia, intrahepatic cholestasis (3)Disorder of coagulation generation or consumption clotting factor→>bd ng tendency (4)Dysfunction of bioconversion drug metabolism; detoxication of toxin, inactivation of hormone (5)Dysfunction of immune(Kuppfer cells bacterial infection, bacteremia, intestinal endotoxemia5 (1) metabolism: (2) bile secrete and excrete: (3) coagulation: (4) bioconversion (5) immune Disturbance of metabolism: carbohydrate, protein, electrolyte Obstacle of bile secrete and excrete: hyperbilirubinemia, intrahepatic cholestasis Disorder of coagulation: generation↓ or consumption↑ → clotting factor↓→ bleeding tendency Dysfunction of bioconversion drug metabolism; detoxication of toxin; inactivation of hormone Dysfunction of immune (Kuppfer cells) bacterial infection, bacteremia, intestinal endotoxemia 3. Function of normal liver 3. Effects of hepatic failure on the body