Regulation of Cortisol Secretion: Feedback Loops Circadian Stress rhythm Hypothalamic Hypothalamus CRH Anterior Pituitary · Adrenal cortex ACTH pituitary Cortisol Adrena CRH: corticotropin-releasing Immune Liv ver Muscle Adipose system tissue hormone Function Gluco- Protein ACTH: Adrenocorticotropic suppressed neogenesis catabolism Lipolysis hormoneRegulation of Cortisol Secretion: Feedback Loops • Hypothalamic • Anterior Pituitary • Adrenal cortex CRH: corticotropin-releasing hormone ACTH: Adrenocorticotropic hormone