二、 Accelerated destruction of red cells 1) Endogenous (intra-erythrocyte defects) 1. Membrane defects of erythrocytes: Hereditary Hereditary spherocytosis (HS) Hereditas elliplocytosis (he) Acquired: PNH 2. Enzyme defects Glucose--6--Phosphate Dehydrogenase G6PD)deficiency Pyruvate kinase deficiency 3.Abnormal haptoglobin synthesis. Sickle cell anemia, Hemoglobinopathies Thalassemias二、Accelerated destruction of red cells 1）Endogenous (intra-erythrocyte defects) 1.Membrane defects of erythrocytes : Hereditary :Hereditary spherocytosis (HS) Hereditasy elliplocytosis (HE) Acquired : PNH 2.Enzyme defects Glucose--6--Phosphate Dehydrogenase (G6PD) deficiency Pyruvate kinase deficiency 3.Abnormal haptogllbin synthesis : Sickle cell anemia, Hemoglobinopathies Thalassemias