5.PLP facilitates the transamination and other transformations of amino acids Different aminotransferases(e. g. aspartate and alanine aminotransferases), each catalyzes the transfer of the amino group from an amino acid to a-ketoglutarate to form Glu and a a-keto acid Pyridoxal phosphate(PLP), being derived from vitamin B (i. e, pyridoxine) and the prosthetic oups for all the aminotransferases, act as a temporary carrier of the amino groups PLP accepts and then donates an amino group by forming a Schiff base with the amino-donating amino acid and amino-accepting a-keto acid(being a-ketoglutarate in many cases respectively.5. PLP facilitates the transaminatin and other transformations of amino acids • Different aminotransferases (e.g., aspartate and alanine aminotransferases), each catalyzes the transfer of the amino group from an amino acid to a-ketoglutarate to form Glu and a a-keto acid. • Pyridoxal phosphate (PLP), being derived from vitamin B6 (i.e., pyridoxine) and the prosthetic groups for all the aminotransferases, act as a temporary carrier of the amino groups. • PLP accepts and then donates an amino group by forming a Schiff base with the amino-donating amino acid and amino-accepting a-keto acid (being a-ketoglutarate in many cases )respectively