D. A. Evans. M. Calter The Aza-Cope Rearrangement Chem 115 (*)-Crinine Overman JACS 1981, 103, 5579 ntermediate A (土 crinine Alternative Routes to intermediate a. OTMS AgNO3. Mannich 32B-0811/24/9310:00AM(±)-Crinine Overman JACS 1981, 103, 5579. 62% NaCNBH3, 88% HCHO, H+, DMSO + 65% Pd/C, cyclohexene, 95% Intermediate A HCHO, H+, 79% 4 steps, 26% overall (±)-crinine Alternative Routes to Intermediate A: + 72% 74% AgNO3, 93% + + + + Mannich 2-aza-Cope Pd/C, Cyclohexene, 95% Intermediate A D. A. Evans, M. Calter The Aza-Cope Rearrangement Chem 115 O N N HO Ph Ph Ph Ph O O O O Li H H O O NH C(H)Ph2 HO HO N C(H)Ph2 O O H N Ar HO R H N R HO Ar H N Ar O R H N O C(H)Ph2 O O H H O O N H O N H O O O O O HO H N OTMS OTMS N H Bn CN N Bn CN O Li O O HO N Bn O O H CN N OH Ar R N R Ar H OH Ar N Bn O N O H Ar H 32B-08 11/24/93 10:00 AM