CH3CCH2TCH2CH2CH2CH3 )NaoCH,Ch CH3 CH,CH,CI B CH3,CH3 CH3 CCHCOOCH2 CH3 SN2 Acetoacetic ester 乙酰乙酸乙酯 Nucleophile reagent Naoh 2)H3O CH3CCH—cH2 CH2CH2CH3 CH3CCH—cH2cH2CH2CH3 水解 COOCH2 CH3 CooNa heat CH3CCH—cH2cH2cHcH3 CH3CCH2+CH2CH2CH2CH3 CO COCH 脱羧CH3 CCH2 O CH2 CH2 CH2 CH3 CH3CCH2COOCH2CH3 O 1) NaOCH2CH3 CH3CCHCOOCH2CH3 O - Na + Acetoacetic ester 乙 酰 乙 酸 乙 酯 Nucleophile reagent CH3CH2CH2CH2 Br SN2 CH3CCH O COOCH2CH3 CH2CH2CH2CH3 1) NaOH 2) H3O + CH3CCH O COONa CH2CH2CH2CH3 CH3CCH O COOH CH2CH2CH2CH3 heat - CO2 CH3CCH2 O CH2CH2CH2CH3 脱 羧 水 解