1956,L.C.Clark:oxygen electrode 1962,L.C.Clark biosensor concept (electrochemical sensor enzyme transducers as membrane enzyme electrode) Glucose 02 H202 Gluconic acid Glass Ag/A▣ Plastic electrode membrane Phosphate Ag anode Blood Sample chamber Pt cathode Polypropylene membrane 03+2H,0+4e→40H oxygen electrode enzyme electrode1956, L.C. Clark : oxygen electrode 1962, L.C. Clark : biosensor concept (electrochemical sensor + enzyme transducers as membrane = enzyme electrode) oxygen electrode enzyme electrode