Organic Chemistry Organic and Biological Chemistry in Modern Medicine Coronary artery disease(CAD)is directly correlated with blood cholesterol leě#病 75%of blood cholesterol (1000 mg a day)is biosynthesized Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels他汀类药物 他汀类降血脂药) 3-Hydroxy-3-methylglutaryI coenzyme A(HMG-CoA)to mevalonate conversion3-羟基-3甲基戊二酰辅酶A Crucial step in biosynthesis of cholesterol Atorvastatin (Lipitor)inactivates enzyme that catalyzes HMG-CoA to mevalonate conversion ▣阿托伐他汀 Organic and Biological Chemistry in Modern Medicine ◆Coronary artery disease (CAD) is directly correlated with blood cholesterol levels ▪ 75% of blood cholesterol (1000 mg a day) is biosynthesized ▪Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels ◆3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate conversion ▪ Crucial step in biosynthesis of cholesterol ▪ Atorvastatin (Lipitor) inactivates enzyme that catalyzes HMG-CoA to mevalonate conversion ▪ 阿托伐他汀 Organic Chemistry 冠状动脉疾病 他汀类药物 3-羟基-3甲基戊二酰辅酶A 他汀类降血脂药）