The Role of Adjuvants Depot effect antigen persists for long period resistance to rapid degradation Macrophage activation production of non-specific enhancing factors Non-specific T cell signal provides "second"signal to B cell normally provided by T cellThe Role of Adjuvants ◼ Depot effect ◼ antigen persists for long period ◼ resistance to rapid degradation ◼ Macrophage activation ◼ production of non-specific enhancing factors ◼ Non-specific T cell signal ◼ provides "second" signal to B cell normally provided by T cell