Prefix %A prefix is a letter or a letter combination placed before a word or a combining form to alter or modify the basic meaning of the word %oA larger proportion of prefixes describe spatial relationship. Others negate concepts, describe physical properties or qualities of objects or conceptsPrefix ❖A prefix is a letter or a letter combination placed before a word or a combining form to alter or modify the basic meaning of the word. ❖A larger proportion of prefixes describe spatial relationship. Others negate concepts, describe physical properties or qualities of objects or concepts