国生 Formulation design 国上生 Product concentrate is the active ingredients ©Container of the aerosol combined with the required adjuncts to prepare a stable and efficacious ·Plastic coated glass product. Metal (aluminum)container ·Active Ingredients Plastic container Solvent or co-solvent Surface active agent ·Others 图上生一 Valve(Metered dose valve) 国生 ©Cap(封帽) Stem(阀门杆) ©Rubber ferrule(橡胶封圈)Spring(弹簧) ©Formulation of MDI ©Metering chamber(定量杯)Dip tube(浸入管) Solution aerosols @Actuator(推动钮) Cosolvent ·Stabilizer ·Surfactant (毕)气粥外形 国坠生一 国话生 ©Formulation of MDI ©Preparation of MDI ·Suspension aerosols ·Pressure filling Control moisture content Reduce initial particle size to less than 5um ·Cold filling Use drug derivatives having minimum solubility .Adjust density of propellant and drug particles Use dispersing agents 55 Shanghai Jiao Tong University Formulation design Product concentrate is the active ingredients of the aerosol combined with the required adjuncts to prepare a stable and efficacious product. • Active Ingredients • Solvent or co-solvent • Surface active agent • Others Shanghai Jiao Tong University Container • Plastic coated glass • Metal (aluminum) container • Plastic container Shanghai Jiao Tong University Valve (Metered dose valve) Cap (封帽) Stem (阀门杆) Rubber ferrule (橡胶封圈) Spring (弹簧) Metering chamber (定量杯) Dip tube(浸入管) Actuator (推动钮) Shanghai Jiao Tong University Formulation of MDI • Solution aerosols • Cosolvent • Stabilizer • Surfactant Shanghai Jiao Tong University Formulation of MDI • Suspension aerosols • Control moisture content • Reduce initial particle size to less than 5um • Use drug derivatives having minimum solubility • Adjust density of propellant and drug particles • Use dispersing agents Shanghai Jiao Tong University Preparation of MDI • Pressure filling • Cold filling