Peculiar Medication in newborns Pharmacokinetics in newborn Physiological status of newborns Pharmacokinetics in newborn Imperfect liver and kidney function Poor metabolism and excretion Great individual difference Dosage can not calculated based on the dosage for adults Imperfect blood-brain barrier Drug easy transfer into brain High Body surface area External drugs easy to be absorbed 6Imperfect liver and kidney function Great individual difference Pharmacokinetics in newborn Peculiar Peculiar Medication in newborns Medication in newborns Poor metabolism and excretion Dosage can not calculated based Physiological status of newborns Physiological status of newborns Pharmacokinetics in Pharmacokinetics in newborn newborn 6 Great individual difference Imperfect Imperfect blood-brain barrier High Body surface area Dosage can not calculated based on the dosage for adults Drug easy transfer into brain External drugs easy to be absorbed