A.General Pharmacological properties 5. COX-1 /COX-2 and selectivity of the drugs COX-1: constructive involved in physiologic regulatory functions in GI tract, kidney, etc. inhibition of cox-1 is related to the adverse effects COX-2: inducible; involved in pathological responses such as inflammation, and pregnancy inhibition of COX-2 is related to the therapeutic effects 出大皆亭5. COX-1 / COX-2 and selectivity of the drugs COX-1: constructive; i n v o l v e d i n p h y s i o l o g i c regulatory functions in GI tract, kidney, etc.; inhibition of COX-1 is related to the adverse effects. COX-2: inducible; involved in pathological responses such as inflammation, and pregnancy; inhibition of COX-2 is related to the therapeutic effects. A. General Pharmacological properties