They are able to differentiate to generate primitive ectoderm OVerlap CDX2 OOCT3 TE 8-cell 16-cell Blastocyst E25 E3.0 E3.5 OGATA6 NAnog Epiblast Pr finitive endoderm Trophectoderm Early blastocyst Late blastocyst E3.5 E4.5 Nature Reviews I Molecular Cell Biology1. They are able to differentiate to generate primitive ectoderm