Receptor topography and classification Type V is cell surface molecule anchored to plasma membrane through a glycosyl-phosphatidyl inositol (GPI)anchor.The two examples shown are neural GPI cell adhesion molecules(GPI-CAMs). Other examples include CD16,also called FcyRIll, CD14.which is associated with Toll-like receptor 4 for signaling.and uPA receptor(uPAR,also called CD87). GPIlinkage A Some GPl-linked receptors are capable of trans- membrane signaling.The mechanism has not yet been fully elucidated. GPI linkage B L 品 Receptor-mediated signaling RTK:receptor tyrosine kinase (e.g.,receptors for EGF,PDGF) Shc:proto-oncogene,adaptor Grb2:adaptor protein MEK Sos:Ras exchange factor ERK Ras:Small GTPase Mnk CYTOPLASM Raf,MEK,ERK:kinases Elk-1:transcription factor NUCLEUS Mnk:a MAPKAPKType V is cell surface molecule anchored to plasma membrane through a glycosyl-phosphatidyl inositol (GPI) anchor. The two examples shown are neural GPI cell adhesion molecules (GPI-CAMs). Other examples include CD16, also called FcγRIII, CD14, which is associated with Toll-like receptor 4 for signaling, and uPA receptor (uPAR, also called CD87). Some GPI-linked receptors are capable of trans￾membrane signaling. The mechanism has not yet been fully elucidated. Receptor topography and classification Receptor‐mediated signaling RTK: receptor tyrosine kinase (e.g., receptors for EGF, PDGF) Shc: proto-oncogene, adaptor Grb2: adaptor protein Sos: Ras exchange factor Ras: Small GTPase Raf, MEK, ERK: kinases Elk-1: transcription factor Mnk: a MAPKAPK