安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Drug Toxicity and Adverse Drug Reactions Chapter:16 Teacher's name: Qiong Huang Grade:2013 Department:Clinical Medicine,School of International Education Time:14:30-16:50 Date(D/M/Y):3/16/2016 1.Recognize the concept of adverse drug reaction and the impact of adverse Teaching drug reactions. Objectives; 2.Recognize the classification of adverse drug reactions. Teaching 3.Recognize the mechanism of drug toxicity. Requirements 4.Master the contexts of drug toxicity. 1.Introduction to adverse drug reaction. 2.The classification of adverse drug reactions. Teaching 3.The mechanism of drug toxicity. Content 4.The contexts of drug toxicity. 5.Questions and discussions. Teaching Teaching Focus:The mechanism of drug toxicity. Focus; Difficult Problems:the classification of adverse drug reactions,the Difficult mechanism of drug toxicity and how to use it in clinical practice Problems Solutions:Give examples of adverse drug reaction and the mechanisms of and their drug toxicity,and discuss about the rational drug therapy in patients. Solutions Introduction to adverse drug reaction 5min Time The classification of adverse drug reactions 10min The mechanism of drug toxicity 18min Allotment The contexts of drug toxicity 4min Questions and discussions 3min 1.The content of drug toxicity mechanism. Assignment 2 Give an example to explain side effect and possible mechanism. 1.Principle of Clinical Pharmacology(Second Edition);Arthur J.Atkinson 2.Basic Clinical Pharmacology;Bertram G.Katzung 3.Classen,DC.Pestotnik,SL.Evans,RS.Lloyd,JF.Burke,JP.Adverse drug events in hospitalized patients.Excess length of stay,extra costs,and Reference attributable mortality.JAMA 1997;277,301-306 Text 4.Lazarou,J.Pomeranz,BH.Corey,PN.Incidence of adverse drug reactions in hospitalized patients:a meta-analysis of prospective studies.N JAMA 1998,279,1200-1205. 5.Need,AC.Motulsky,AG.Goldstein,DB.Priorities and standards in pharmacogenetic research.Nat Genet 2005;37,671-681安徽医科大学国际教育学院教案与讲稿 1 Teaching Plan for International Students, AHMU Title of the course: Drug Toxicity and Adverse Drug Reactions Chapter: 16 Teacher’s name: Qiong Huang Grade: 2013 Department: Clinical Medicine, School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/16/2016 Teaching Objectives; Teaching Requirements 1. Recognize the concept of adverse drug reaction and the impact of adverse drug reactions. 2. Recognize the classification of adverse drug reactions. 3. Recognize the mechanism of drug toxicity. 4. Master the contexts of drug toxicity. Teaching Content 1. Introduction to adverse drug reaction. 2. The classification of adverse drug reactions. 3. The mechanism of drug toxicity. 4. The contexts of drug toxicity. 5. Questions and discussions. Teaching Focus; Difficult Problems and their Solutions Teaching Focus: The mechanism of drug toxicity. Difficult Problems: the classification of adverse drug reactions, the mechanism of drug toxicity and how to use it in clinical practice Solutions: Give examples of adverse drug reaction and the mechanisms of drug toxicity, and discuss about the rational drug therapy in patients. Time Allotment Introduction to adverse drug reaction 5min The classification of adverse drug reactions 10min The mechanism of drug toxicity 18min The contexts of drug toxicity 4min Questions and discussions 3min Assignment 1. The content of drug toxicity mechanism. 2 Give an example to explain side effect and possible mechanism. Reference Text 1. Principle of Clinical Pharmacology (Second Edition); Arthur J. Atkinson 2. Basic & Clinical Pharmacology; Bertram G. Katzung 3. Classen, DC. Pestotnik, SL. Evans, RS. Lloyd, JF. Burke, JP. Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. JAMA 1997; 277, 301-306 4. Lazarou, J. Pomeranz, BH. Corey, PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. N JAMA 1998; 279,1200-1205. 5. Need, AC. Motulsky, AG. Goldstein, DB. Priorities and standards in pharmacogenetic research. Nat Genet 2005; 37, 671-681