国生 Direct compression 国生 Direct compression 国生 Tablet apparatus Advantages of Direct Compression Disadvantages of Direct Compression Simplicity and economy Can not be used for all drug substances ·Fewer operations Higher demand on flowability and Fewer plants comp:atibility Less energy consumption More expensive excipiens 多Rotary press Less processing times .Segregation potential ·Stability .Better disintegration ©t生Evaluation of compressibility 国生Evalution of compessibili的y 国生Evaluation of compressibility Hardness硬度 Breakage,.BK脆碎度 ©Elastic recovery,ER弹性回复率 Monsanto hardness tester Rchc碎度测定仪 , E.-'-5=H-Lx100% 。H Tensile strength抗张强度 T3=2F/x·DL 最初片重 1212 Shanghai Jiao Tong University Direct compression Advantages of Direct Compression • Simplicity and economy • Fewer operations • Fewer plants • Less energy consumption • Less processing times • Stability • Better disintegration Shanghai Jiao Tong University Direct compression Disadvantages of Direct Compression • Can not be used for all drug substances • Higher demand on flowability and compatibility • More expensive excipients • Segregation potential Shanghai Jiao Tong University Tablet apparatus Single punch press Rotary press Shanghai Jiao Tong University Shanghai Jiao Tong University 物料 下冲 上冲 片剂 模圈 刮板 Shanghai Jiao Tong University Evaluation of compressibility Hardness 硬度 • Monsanto hardness tester Tensile strength抗张强度 TS  2F   D  L Shanghai Jiao Tong University Evaluation of compressibility Breakage, BK脆碎度 100%   最初片重 最初片重 最终片重 脆碎度 Roche脆碎度测定仪 Shanghai Jiao Tong University Evaluation of compressibility Elastic recovery, ER弹性回复率 100% 0 0 0 0      H H H V V V ER