T Cell Biology Within ER, class I MHC heavy chain synthesized and associates with B2 microglobulin Dimer binds peptide plasma membrane If peptide is foreign passing CD8+ T cell (cytotoxic) recognizes, releases cytokines destroys cell BIOL 533 Lecture 7BIOL 533 11 Lecture 7 T Cell Biology • Within ER, class I MHC heavy chain synthesized and associates with 2 microglobulin • Dimer binds peptide plasma membrane • If peptide is foreign, passing CD8+ T cell (cytotoxic) recognizes, releases cytokines, destroys cell