Structural Diversity Gymnorrhizol Structural Diversity aricin 氟代酸基 的第 pathee D Cm o7. Structural Diversity Ingenamine G Symmetric Marine Compounds Symmetric Marine Compounds Aerothionin 1 33 S S S S S NH2 OMe MeO Varicin was isolated from algae Lissoclinun vareau, 中分离 的第一个天然存在的环状多硫化合物，Varicin有十分显著的 抗肿瘤活性。在人肠癌试管混合实验时，其活性比已知的治 疗药物5-氟尿嘧啶细胞毒性高100倍。 Varicin Gymnorrhizol, an unusual macrocyclic polydisulfide possessing an unprecedented carbon skeleton, has been isolated from a mangrove Bruguiera gymnorrhiza (Guangxi). Guo YW, TL 2004, 45, 5533. Structural Diversity Gymnorrhizol 34 O OH Cl N Cl Cl Cl OH NaO3SO OH OH OSO2NHMe Faulkner D. J. J. Am. Chem. Soc. 1977, 99, 7367. Faulkner D. J. Tetrahedron. 1999, 55, 8323. Structural Diversity Marine Sponges Special residue 二氯代亚胺基 扩大了天然存在 的基团的概念 35 Structural Diversity The structure elucidation of Aplasmomycin A was performed by X-ray crystallographic methods. To the surprise, the molecule contained an unexpected Boron atom in the center of the complex. Nakamura, H.; et al. Antibiot. 1977, 30, 714. 36 Ingenamine G Ingenamine G was isolated from marine Sponge Pachychalina sp. Which displayed cytotoxic activity against HCT-8 (colon), B16 (leukemia), and MCF-7 (breast) cancer cell lines. Oliveira, J. H. H. L. et al. J. Nat. Prod. 2004, 67, 1685. 37 Cyclostellettamines G, H, I, K and L Cyclostellettamines G, H, I, K and L were also isolated from marine sponge Pachychalina sp. Symmetric Marine Compounds 38 Aerothionin The sponges Aplysia aerophoba and Verongia thiona have yielded the antibiotic substance, Aerothionin having a spiro cyclohexadienylisoxazole skeleton. Encarnacion, R. D.; Sandoval, E.; Christophersen, C. J. Nat. Prod. 2000, 63, 874. Symmetric Marine Compounds