What can distinguish pathologic hyperplasia from cancer? If the signals that initiate it abate,cell proliferation is "turned off"by various growth inhibitors and the hyperplasia disappears. o It is this responsiveness to normal regulatory control mechanisms that distinguishes pathologic hyperplasia from cancer,in which the growth control mechanisms become dysregulated or ineffective. What can distinguish pathologic hyperplasia from cancer?  If the signals that initiate it abate, cell proliferation is “turned off” by various growth inhibitors and the hyperplasia disappears.  It is this responsiveness to normal regulatory control mechanisms that distinguishes pathologic hyperplasia from cancer, in which the growth control mechanisms become dysregulated or ineffective