3. Gap Junction in Diseases Connexin gene mutation and diseases Congenital non-syndromatic deafness(Cx26 mutation) Congenital cataract(Cx50 mutation Axonal degeneration of peripheral nerves(CX32 mutation) Infertility of females( Cx37) Gap junction and tumor promotion Gap junction intercellular communication down-regulated Gap junction and embryogenesis embryo development(Cx43) nutrients transportation( Cx26) Others3. Gap Junction in Diseases • Connexin gene mutation and Diseases – Congenital non-syndromatic deafness (Cx26 mutation) – Congenital cataract (Cx50 mutation) – Axonal degeneration of peripheral nerves (Cx32 mutation) – Infertility of females (Cx37) • Gap junction and tumor promotion -- Gap junction intercellular communication down-regulated • Gap junction and embryogenesis -- embryo development (Cx43) -- nutrients transportation (Cx26) • Others