Primary complement deficiencies Component (or subunit) Gene symbol Chromosomal location C1q:a chain CIQA 1p34.1-p36.3 CIq:B chain 1●)PB 1p34.1-p36.3 C1q:Y chain C1OG 1p34.1-p36.3 C8:a chain C8A 1p32 C8:B chain C8B 1p32 C4 Binding Protein:a chain C4BPA 1q32 C4 Binding Protein:B chain C4BPB 1g32 Complement Receptor 1(CD 35) CRI 1q32 Complement Receptor 2(CD 21) CR2 1q32 Decay Accelerating Factor (CD 55) DAF 1q32 Membrane Cofactor Protein(CD 46) MCP 1q32 Factor H HF 1q32 Factor I IF 4q25 6 6 5p13 7 C7 5p13 C9 C9 5p13 C2 C2 6p21.3 Factor B BF 6p21.3 C4A (isotype) C4A 6p21.3 C4B (isotype) C4B 65p21.3 C8:y chain C8G 9a22.3-g32 C5 9a33 Mannose Binding Lectin MBL 10q11.2-q21 Perforin PRF1 10q22 Surfactant Proteins Al and A2 SFTPA1,A2 10g22-q23 Surfactant Protein D SFTPD 10q22-q23 Membrane Inhibitor of Reactive Lysis CD59 11p13 (MIRL,CD59) C1 Inhibitor CINH 11q11-q13.1 C1r CIR 12p13 CIs CIS 12p13 Complement Receptor 3:a chain, ITGAM 16p11.2 =a-M Integrin(CR3A,CD11A) Vitronectin (S-protein) VTN 17g11 C3 3 19p13,3-p13.2 CSa receptor 1 C5R1 19q13.3-q13.4 Leucocyte Adhesion Molecule:B chain, ITGB2 21q22.3 B-2 Integrin (LCAMB,CD18) Properdin PFC Xp11.4-p11.2 Component (or subunit) Gene symbol Chromosomal location C1q:  chain C1QA 1p34.1-p36.3 C1q:  chain C1QB 1p34.1-p36.3 C1q:  chain C1QG 1p34.1-p36.3 C8:  chain C8A 1p32 C8:  chain C8B 1p32 C4 Binding Protein:  chain C4BPA 1q32 C4 Binding Protein:  chain C4BPB 1q32 Complement Receptor 1 (CD 35) CR1 1q32 Complement Receptor 2 (CD 21) CR2 1q32 Decay Accelerating Factor (CD 55) DAF 1q32 Membrane Cofactor Protein (CD 46) MCP 1q32 Factor H HF 1q32 Factor I IF 4q25 C6 C6 5p13 C7 C7 5p13 C9 C9 5p13 C2 C2 6p21.3 Factor B BF 6p21.3 C4A (isotype) C4A 6p21.3 C4B (isotype) C4B 6p21.3 C8:  chain C8G 9q22.3-q32 C5 C5 9q33 Mannose Binding Lectin MBL 10q11.2-q21 Perforin PRF1 10q22 Surfactant Proteins A1 and A2 SFTPA1, A2 10q22-q23 Surfactant Protein D SFTPD 10q22-q23 Membrane Inhibitor of Reactive Lysis (MIRL, CD59) CD59 11p13 C1 Inhibitor C1NH 11q11-q13.1 C1r C1R 12p13 C1s C1S 12p13 Complement Receptor 3:  chain, = -M Integrin (CR3A, CD11A) ITGAM 16p11.2 Vitronectin (S-protein) VTN 17q11 C3 C3 19p13.3-p13.2 C5a receptor 1 C5R1 19q13.3-q13.4 Leucocyte Adhesion Molecule:  chain, = -2 Integrin (LCAMB, CD18) ITGB2 21q22.3 Properdin PFC Xp11.4-p11.2 Primary complement deficiencies