Patients often exhausted and confused Occasionally, patients lose bladder and or bowel control Anticonvulsant medication Often lifelong Can have major effects on quality of life Earliest is bromide(1857) Potassium bromide - impotence in men Phenobarbital ( 1912) Phenytoin(1930) currently about 20 common ones• Patients often exhausted and confused • Occasionally, patients lose bladder and or bowel control • Anticonvulsant medication – Often lifelong – Can have major effects on quality of life – Earliest is bromide (1857) – Potassium bromide – impotence in men. – Phenobarbital (1912) – Phenytoin (1930) – Currently about 20 common ones