Protein Design as an Inverse Folding Problem Goal: come up with a sequence that folds to give a protein-like structure with some desired properties Examples of design goals a pre-defined structure/fold a desired oligomerization state enhanced thermal stability ability to bind a given ligand ability to catalyze a certain reactionProtein Design as an Inverse Folding Problem Goal: come up with a sequence that folds to give a protein-like structure with some desired properties Examples of design goals: • a pre-defined structure/fold • a desired oligomerization state • enhanced thermal stability • ability to bind a given ligand • ability to catalyze a certain reaction