Hematopoiesis: a model of svstems biomedicine Common Myeloid c○ Common Lymphoid Progenitor(c Progenitor (CLP) cD33·,cD34+,cD38 Hematopoietic CD10*, CD38+, TaT Stem Cell(HSC) cD34+,cD38 EMP BFU-E BFU-meg GMP CFU-baso T-cell B-cell cD33+ CD34+ cD13+,cD33 CD34+ progenitor progenitor CD34+ cD34+ CD2+, CD4+ CD38+,cD34+ IL-3 CD5+, CD7+ cD24+,cD19+ GM-CSF lL·11 L-3 L-6 lL·10 L·1 Pre-Pre-B GM-CSF CFU-E CFU-meg CFU-M CFU-G CFU-Eos IL-4. SF CD36 CSF-1 G-CSF GM-CSF GM-CSF Pre-B IL-4. IL-5 GM-CSF L-6.L-11 B cell IL-6. TP CSF.t lL-8) ast ce L-4.L-5.lL6 RBC platelets Mono Important players: Hematopoietic stem cells, cytokines, microenvironmentHematopoiesis: a model of systems biomedicine Common Myeloid Progenitor (CMP) Hematopoietic Stem Cell (HSC) Common Lymphoid Progenitor (CLP) GMP EMP Important players: Hematopoietic stem cells, cytokines, microenvironment