BIOSYNTHESIS OF MINERALOCORTICOIDS HO pregnenolone 18-hydroxy corticosterone Aldosterone HO HOCH2 d HOCH HOCH2 HO. HOCH2 HO cH人 HO HO e progesterone deoxycortico g o cortico sterone sterone 5-ene-3β- hydroxy OH CH2OH dehydrogenase d. 3-0X0-45-isomerase o—cH e. 21-hydroxylase Aldosterone f. 11B-hydroxylase hemiacetal form)f g. 18-hydroxylaseBIOSYNTHESIS OF MINERALOCORTICOIDS HO HO O HOCH2 O O O O HOCH2 O O HO O HO C HOCH2 CH2 HO O O HO HOCH2 CH O O O HO CH2OH CH O OH progesterone deoxycortico￾sterone cortico￾sterone 18-hydroxy￾corticosterone Aldosterone Aldosterone (hemiacetal form) pregnenolone c,d e f g c. 5-ene-3b-hydroxy dehydrogenase d. 3-oxo-4,5-isomerase e. 21-hydroxylase f. 11b-hydroxylase g. 18-hydroxylase