SURROGATE ENDPOINT A biomarker intended to substitute for a clinical endpoint. A surrogate endpoint is expected to predict clinical benefit (or harm,or lack of benefit)based on epidemiologic,therapeutic,pathophysiologic or other scientific evidence. 12A biomarker intended to substitute for a clinical endpoint. A surrogate endpoint is expected to predict clinical SURROGATE ENDPOINT 12 benefit (or harm, or lack of benefit) based on epidemiologic, therapeutic, pathophysiologic or other scientific evidence