1. Fatty acid synthesis takes a different pathway from its degradation o Occurs in the cytosol(chloroplasts in plants o Acetyl-CoA provides the first two carbons which is elongated by sequential addition of two-carbon units donated from malonyl-COA o Intermediates are attached to the -sh groups of an acyl carrier protein (ACP) o NAdPh is the reductant o The enzymes are associated as a multi-enzyme complex or even being in one polypeptide chain in higher organisms(fatty acid synthase)1. Fatty acid synthesis takes a different pathway from its degradation ⚫ Occurs in the cytosol (chloroplasts in plants). ⚫ Acetyl-CoA provides the first two carbons, which is elongated by sequential addition of two-carbon units donated from malonyl-CoA. ⚫ Intermediates are attached to the -SH groups of an acyl carrier protein (ACP). ⚫ NADPH is the reductant. ⚫ The enzymes are associated as a multi-enzyme complex or even being in one polypeptide chain in higher organisms (fatty acid synthase)