T-Dependent mechanism The number of b cells increase T-helper cells produce other cytokines(BCDF These cause some B cells to stop dividing, differentiating into plasma cells and produce ab Also B cell recognizes its Ag through its surface IgM receptor(signal #1 for b cell), subsequently triggered to proliferate plasma cells ab BIOL 533 Lecture 7BIOL 533 8 Lecture 7 T-Dependent Mechanism • The number of B cells increase, T-helper cells produce other cytokines (BCDF) – These cause some B cells to stop dividing, differentiating into plasma cells and produce Ab – Also B cell recognizes its Ag through its surface IgM receptor (signal #1 for B cell), subsequently triggered to proliferate plasma cells Ab