图上生 国生 Physicochemical properties of gelatin ©Size of shells ·Eight size:000,00,0,1,2,3,4,5 ·Bloom strength gives an indication of the firmness of Calculated fill weight (g)at Size Volume (32) powder density of 0.8 g/em' the gel 000 1.37 1.096 00 0.95 0.760 ·Viscosity 0.68 0.544 050 0.400 Be vital to the control of the thickness 3 037 0.296 0.30 0,240 of the cast film 021 0.168 0.13 0.104 国生一 国生一 Other components in shell of hard capsules ·Plasticizer Sealing and Self-locking closure ·Thicker Self-locking ·Colorant ·Band sealing ·Spot welding ·Opacifier ·Preservative ·Water 国生一 圈生 ©Shell manufacture ·Gelatin dissolution Oxygen permeation through size00 gelatin capsules ·Dipping Oxygen permeation rate (mL24 hr) ·Rotation Traditiceal nonlcking Locking" (not banded) e ·Drying ·Stripping ·Trimming Joining ·Sorting .Printing 22 Shanghai Jiao Tong University Physicochemical properties of gelatin • Bloom strength • gives an indication of the firmness of the gel • Viscosity • Be vital to the control of the thickness of the cast film Shanghai Jiao Tong University Other components in shell of hard capsules • Plasticizer • Thicker • Colorant • Opacifier • Preservative • Water Shanghai Jiao Tong University Shell manufacture • Gelatin dissolution • Dipping • Rotation • Drying • Stripping • Trimming • Joining • Sorting • Printing Shanghai Jiao Tong University Size of shells • Eight size: 000, 00, 0, 1, 2, 3, 4, 5 Shanghai Jiao Tong University Sealing and Self-locking closure • Self –locking • Band sealing • Spot welding Shanghai Jiao Tong University Oxygen permeation through size 00 gelatin capsules