Symptoms Functioning tumors, which are rare, can increase risk of mortality. These active tumors secrete catecholamines which can lead to clinical manifestations of hypertension, headaches, palpitations and tachycardiaSymptoms ◼ Functioning tumors, which are rare, can increase risk of mortality. These active tumors secrete catecholamines, which can lead to clinical manifestations of hypertension, headaches, palpitations, and tachycardia