Medical Genetics Laboratory Muscle pathology No ragged red fibers EOM mitochondria: Diffuse increase in number and size, Disorganized cristae Preservation of myofibrils MRI: Optic nerve may enhance on T2 weighted imagesMedical Genetics Laboratory • Muscle pathology – No ragged red fibers – EOM mitochondria: Diffuse increase in number and size; Disorganized cristae – Preservation of myofibrils • MRI: Optic nerve may enhance on T2 weighted images