The killer bean of Calabar “审判豆” John Hutton Balfour Robert Christison Thomas Richard Fraser (1808-1884) (1797-1882) Physostigma (1841-1920) Scottish botanist J.H.Balfour's Student venenosum R.Christison's Student Identified Plant i 1861 Isolated Eserine in 1863 Calabar bean Antagonism between physostigmine and atropine Antagonism Between Curare and Physostigmine 'Physostigmine,an Antidote to Curare