Normal modes of proteins sometimes correspond to biologically relevant motions shearing"or hinging"conformational changes are common in enzymes Can compare structure changes computed from Nma with alternate conformations observed experimentally. frequently a low-frequency mode describes the change(but it may not be the lowest energy mode) NMa is a way to get an idea about motion from a static structureNormal modes of proteins sometimes correspond to biologically relevant motions • “shearing” or “hinging” conformational changes are common in enzymes • Can compare structure changes computed from NMA with alternate conformations observed experimentally. Frequently a low-frequency mode describes the change (but it may not be the lowest energy mode) • NMA is a way to get an idea about motion from a static structure